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If you inject heroin or other drugs, you should really test every time you inject. The best method is to test the residue from your spoon or cooker.
The best method for testing powders, crystals or tablets is to test every bit you intend to consume. This requires dissolving you entire dose in water, which means you will need to drink your dose if you decide to take it. For drugs like cocaine or meth that many people like to snort, drinking it will still work. It will take longer to feel the effects, but they will last longer.
CAUTION! This is NOT the recommended method for testing. The best method is to test every bit you intend to consume, as described above. However, some people may not be willing to dissolve their entire dose of drugs in water every time they partake. In that case, the next best method is to test the residue stuck to the inside of the baggie the drugs came in. This method may not detect fentanyl due to the chocolate chip cookie effect, but it is better than not testing at all.